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Abbreviations BL/6J: C57BL/6J BL/6N: C57BL/6N [Ca 2+ ] i : Intracellular Ca 2+ concentration E GSH : Glutathione redox state FCCP: Carbonyl cyanide-trifluoromethoxyphenylhydrazone GRX1: Glutaredoxin 1 GSIS: Glucose-stimulated insulin secretion mt: Mitochondria-targeted NNT: Nicotinamide nucleotide transhydrogenase N5-Tr: N5/BL mice expressing Nnt Tr N5-WT: N5/BL mice expressing Nnt WT roGFP2: Redox-sensitive enhanced GFP Tr: Truncated WGS: Whole genome sequencing WT: Wild-type References Henquin JC (2000) Triggering and amplifying pathways of regulation of insulin secretion by glucose

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Sleep is made up of so many different stages and is influenced by so many factors many of which are still unknown that almost any biologically active compound may be related to some stage or other in sleep

Removal of chylomicron remnants from the bloodstream is delayed in aged subjects

Figure 1: Changes in gross morphological scores amongst the four experimental treatment groups

10.1136/tsaco-2020-000595 86 StrbeS.GojkovicS.KrezicI.ZizekH.VranesH.BarisicI.et al (2021)